Reply—Nonimmune Hydrops Fetalis and Lysosomal Storage Diseases

Lysosomal storage diseases in non-immune hydrops fetalis pregnancies.

BACKGROUND At least 20 inborn errors of metabolism may cause hydrops fetalis. Most of these are lysosomal storage diseases. The study proposes a diagnostic flowchart for prenatal diagnosis of non-immune hydrops fetalis. METHODS This study contains a series of 75 non-immune hydrops fetalis pregnancies. Mucopolysaccharides, oligosaccharides, neuraminic acid and 21 lysosomal enzymes were measure...

[Non-immunologic hydrops fetalis].

Non-immune hydrops fetalis

Aetiology of hydrops fetalis.

These 2 cases provide additional examples of HUS occurring in sibs after a long interval. The family resided in New York City, which is not considered as an endemic area for HUS, and the clinical course of the disease in both infants was almost identical, culminating in early death. The aetiology of HUS may indeed be multiple, and the genetic basis for a significant proportion of cases does not...

Non immune hydrops fetalis.

With the decline in the frequency of rhesus isoimmunisation, hydrops fetalis secondary to other factors is becoming increasingly recognised. We describe a case in association with chorioangioma of the placenta. The causes of non immune hydrops are reviewed and the problems of management discussed.